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Transcutaneous Carbon Dioxide Profile During Sleep Reveals Metabolic Risk Factors in Post-Menopausal Females

Jenni Aittokallio, Tarja Saaresranta, Arho Virkki, Nina Karppinen, Olli J. Heinonen, Tero Aittokallio, Olli Polo, Transcutaneous Carbon Dioxide Profile During Sleep Reveals Metabolic Risk Factors in Post-Menopausal Females. European Respiratory Journal 34, 1132–1139, 2009.

http://dx.doi.org/10.1183/09031936.00017909

Abstract:

The risks of metabolic syndrome and sleep-disordered breathing increase around
the time of the menopause. We have previously shown that features of the nocturnal
transcutaneous carbon dioxide (TcCO2) profile are associated with metabolic variables such as
cholesterol, glycosylated haemoglobin A1C (GHbA1C) and blood pressure in patients with sleep
apnoea. In the present study, we investigated whether these metabolic variables can be predicted
using noninvasive TcCO2 measurements during sleep in generally healthy post-menopausal
females.
22 post-menopausal females underwent an overnight polygraphic sleep study that involved the
continuous monitoring of arterial oxygen saturation (Sa,O2) and TcCO2. Body composition,
GHbA1C, plasma cholesterol and blood pressure were measured prior to the sleep study.
Nocturnal TcCO2 features were the most important predictors of lipoprotein cholesterols,
triglycerides and blood pressure levels. A longer sleep period and higher TcCO2 levels were
linked with lower GHbA1C, and fragmented sleep with lower high-density lipoprotein cholesterol.
Neither nocturnal Sa,O2 indices nor the apnoea/hypopnoea index had a predictive power.
The results suggest that nocturnal TcCO2 events revealed metabolic risk factors already
present in healthy post-menopausal females.

BibTeX entry:

@ARTICLE{jAiSaViKaHeAiPo09a,
  title = {Transcutaneous Carbon Dioxide Profile During Sleep Reveals Metabolic Risk Factors in Post-Menopausal Females},
  author = {Aittokallio, Jenni and Saaresranta, Tarja and Virkki, Arho and Karppinen, Nina and Heinonen, Olli J. and Aittokallio, Tero and Polo, Olli},
  journal = {European Respiratory Journal},
  volume = {34},
  pages = {1132–1139},
  year = {2009},
}

Belongs to TUCS Research Unit(s): Biomathematics Research Unit (BIOMATH)

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