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Probabilistic Analysis of Probe Reliability in Differential Gene Expression Studies with Short Oligonucleotide Arrays

Leo Lahti, Laura L. Elo, Tero Aittokallio, Samuel Kaski, Probabilistic Analysis of Probe Reliability in Differential Gene Expression Studies with Short Oligonucleotide Arrays. IEEE-ACM Transactions on Computational Biology and Bioinformatics 8(1), 217–225, 2011.

Abstract:

Probe defects are a major source of noise in gene expression studies. While existing approaches detect noisy probes based on external information such as genomic alignments, we introduce and validate a targeted probabilistic method for analyzing probe reliability directly from expression data and independently of the noise source. This provides insights into the various sources of probe-level noise and gives tools to guide probe design.

BibTeX entry:

@ARTICLE{jLaElAiKa11a,
  title = {Probabilistic Analysis of Probe Reliability in Differential Gene Expression Studies with Short Oligonucleotide Arrays},
  author = {Lahti, Leo and Elo, Laura L. and Aittokallio, Tero and Kaski, Samuel},
  journal = {IEEE-ACM Transactions on Computational Biology and Bioinformatics},
  volume = {8},
  number = {1},
  pages = {217–225},
  year = {2011},
}

Belongs to TUCS Research Unit(s): Biomathematics Research Unit (BIOMATH)

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