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A Simple Mass-Action Model for the Eukaryotic Heat Shock Response and its Mathematical Validation

Ion Petre, Andrzej Mizera, Claire Hyder, Annika Meinander, Andrey Mikhailov, Richard Morimoto, Lea Sistonen, John Eriksson, Ralph-Johan Back, A Simple Mass-Action Model for the Eukaryotic Heat Shock Response and its Mathematical Validation. Natural Computing 10(1), 595–612, 2011.

Abstract:

The heat shock response is a primordial defense mechanism against cell stress
and protein misfolding. It proceeds with the minimum number of mechanisms that any
regulatory network must include, a stress-induced activation and a feedback regulation,
and can thus be regarded as the archetype for a cellular regulatory process. We propose
here a simple mechanistic model for the eukaryotic heat shock response, including its
mathematical validation. Based on numerical predictions of the model and on its sensitivity
analysis, we minimize the model by identifying the reactions with marginal contribution to
the heat shock response. As the heat shock response is a very basic and conserved regulatory
network, our analysis of the network provides a useful foundation for modeling
strategies of more complex cellular processes.

BibTeX entry:

@ARTICLE{jPeMiHyMeMiMoSiErBa11a,
  title = {A Simple Mass-Action Model for the Eukaryotic Heat Shock Response and its Mathematical Validation},
  author = {Petre, Ion and Mizera, Andrzej and Hyder, Claire and Meinander, Annika and Mikhailov, Andrey and Morimoto, Richard and Sistonen, Lea and Eriksson, John and Back, Ralph-Johan},
  journal = {Natural Computing},
  volume = {10},
  number = {1},
  pages = {595–612},
  year = {2011},
  keywords = {Heat shock response; Heat shock protein; Heat shock factor; Heat shock element; Mathematical model; Validation; Regulatory network},
}

Belongs to TUCS Research Unit(s): Computational Biomodeling Laboratory (Combio Lab)

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