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Proliferation Marker Securin Identifies Favourable Outcome in Invasive Ductal Breast Cancer

Kati Talvinen, Johannes Tuikkala, Olli Nevalainen, A Rantanen, Pirkko Hirsimäki, Jari Sundström, Pauliina Kronqvist, Proliferation Marker Securin Identifies Favourable Outcome in Invasive Ductal Breast Cancer. British Journal of Cancer 99, 335–340, 2008.

Abstract:

We introduce a new proliferation marker, securin (pituitary tumour-transforming 1 (PTTG1)), analysed in invasive ductal breast carcinomas by cDNA microarrays and immunohistochemistry. In cDNA microarray of a total of 4000 probes of genes, securin was revealed with a significant change in expression among the several proliferation-related genes studied. The value of securin as a proliferation marker was verified immunohistochemically (n=44) in invasive ductal breast cancer. In follow-up analyses of the sample of patients, the prognostic value of securin was compared with the established markers of breast cancer proliferation, Ki-67 and mitotic activity index (MAI). Our results of a small sample of patients suggest that low securin expression identifies a distinct subgroup of more favourable outcome among patients with high Ki-67 immunoexpression or high MAI. In univariate analysis of Cox's regression, 10-unit increment of securin immunopositivity was associated with a 2.3-fold overall risk of death due to breast cancer and a 7.1-fold risk of death due to breast cancer in the sample of patients stratified according to the cutoff points of 10 and 20% of securin immunopositivity. We suggest that securin immunostaining is a promising and clinically applicable proliferation marker. The finding urges further prognostic studies with a large sample of patients.

BibTeX entry:

@ARTICLE{jTaTuNeRaHiSuKr08a,
  title = {Proliferation Marker Securin Identifies Favourable Outcome in Invasive Ductal Breast Cancer},
  author = {Talvinen, Kati and Tuikkala, Johannes and Nevalainen, Olli and Rantanen, A and Hirsimäki, Pirkko and Sundström, Jari and Kronqvist, Pauliina},
  journal = {British Journal of Cancer},
  volume = {99},
  pages = {335–340},
  year = {2008},
  keywords = {securin, breast cancer, cDNA microarray, immunohistochemistry, proliferation, prognosis},
}

Belongs to TUCS Research Unit(s): Algorithmics and Computational Intelligence Group (ACI)

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