• TUCS Publication Series
• How to Publish in TUCS Series
• Publication Search
• Publication Graph
• Publication Input
• Publication Input Guide
• JuFo Browser

Quantitative Petri Nets Models for the Heat Shock Response

Diana-Elena Gratie, Ion Petre, Quantitative Petri Nets Models for the Heat Shock Response. TUCS Technical Reports 1068, TUCS, 2013.

Abstract:

The eukaryotic heat shock response is a highly conserved defense mechanism against cellular stress. We propose in this paper a quantitative Petri net-based representation of the heat shock response model introduced in [1]. We consider both a continuous and a stochastic representation, and analyze the properties of the networks. We extend the models to account for the heat-induced degradation of the self-defense mechanism itself, as well as its ability to repair itself. We conclude with an analysis of the simulation results, and a discussion on how modeling biological systems with Petri nets scales with further expansions of the model.

Files:

Full publication in PDF-format

BibTeX entry:

@TECHREPORT{tGrPe13a,
  title = {Quantitative Petri Nets Models for the Heat Shock Response},
  author = {Gratie, Diana-Elena and Petre, Ion},
  number = {1068},
  series = {TUCS Technical Reports},
  publisher = {TUCS},
  year = {2013},
  keywords = {Petri nets, reaction-based models, heat shock response, P-invariants, T-invariants.},
  ISBN = {978-952-12-2854-4},
}

Belongs to TUCS Research Unit(s): Computational Biomodeling Laboratory (Combio Lab)

Edit publication