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A New Mathematical Model for the Heat Shock Response

Ion Petre, Andrzej Mizera, Claire L. Hyder, Andrey Mikhailov, John E. Eriksson, Lea Sistonen, Ralph-Johan Back, A New Mathematical Model for the Heat Shock Response. In: Anne Condon, David Harel, Joost N. Kok, Arto Salomaa, Erik Winfree (Eds.), Algorithmic Bioprocesses, 411–425, Springer, 2009.

Abstract:

We present in this paper a novel molecular model for the gene regulatory network responsible for the eukaryotic heat shock response. Our model includes the temperature-induced protein misfolding, the chaperone activity of the heat shock proteins, and the backregulation of their gene transcription. We then build a mathematical model for it, based on ordinary differential equations. Finally, we discuss the parameter fit and the implications of the sensitivity analysis for our model.

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BibTeX entry:

@INBOOK{cPeMiHyMiErSiBa08a,
  title = {A New Mathematical Model for the Heat Shock Response},
  booktitle = {Algorithmic Bioprocesses},
  author = {Petre, Ion and Mizera, Andrzej and Hyder, Claire L. and Mikhailov, Andrey and Eriksson, John E. and Sistonen, Lea and Back, Ralph-Johan},
  editor = {Condon, Anne and Harel, David and Kok, Joost N. and Salomaa, Arto and Winfree, Erik},
  publisher = {Springer},
  pages = {411–425},
  year = {2009},
  keywords = {Heat shock response, heat shock protein, heat shock factor, mathematical model, differential equations, model fit, sensitivity analysis},
}

Belongs to TUCS Research Unit(s): Software Construction Laboratorium, Computational Biomodeling Laboratory (Combio Lab)

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