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A New Mathematical Model for the Heat Shock Response

Ion Petre, Andrzej Mizera, Claire Hyder, Andrey Mikhailov, John Eriksson, Lea Sistonen, Ralph-Johan Back, A New Mathematical Model for the Heat Shock Response. In: Ion Petre, Ralph-Johan Back (Eds.), Proceedings of COMPMOD 2008: Workshop on Computational Models for Cell Processes, 39-52, Turku Centre for Computer Science (TUCS), 2008.

Abstract:

We present in this paper a novel molecular model for the gene regulatory network
responsible for the eukaryotic heat shock response. Our model includes the
temperature-induced protein misfolding, the chaperone activity of the heat shock proteins and the backregulation of their gene transcription. We then build a mathematical model for it, based on ordinary differential equations. Finally, we discuss the parameter fit and the implications of the sensitivity analysis for our model.

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BibTeX entry:

@INPROCEEDINGS{inpPeMiHyMiErSiBa08a,
  title = {A New Mathematical Model for the Heat Shock Response},
  booktitle = {Proceedings of COMPMOD 2008: Workshop on Computational Models for Cell Processes},
  author = {Petre, Ion and Mizera, Andrzej and Hyder, Claire and Mikhailov, Andrey and Eriksson, John and Sistonen, Lea and Back, Ralph-Johan},
  number = {47},
  editor = {Petre, Ion and Back, Ralph-Johan},
  publisher = {Turku Centre for Computer Science (TUCS)},
  pages = {39-52},
  year = {2008},
  keywords = {Heat shock response, mathematical model, differential equations, model fit, sensitivity analysis},
}

Belongs to TUCS Research Unit(s): Computational Biomodeling Laboratory (Combio Lab)

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